Histopathology of Reversible Cataracts Produced by Hydroxyurea in witro Ikuo
نویسنده
چکیده
A DNA synthesis inhibitoT, hvdroxyurea (HU} CS× 10-2M), was added to the oTgan culture medium for a rat crystalline lens (male, white Wistar rats weighing 1OO g) . 1. 0n the 3rd day, a macroscopic examination revealcd diffuse opacity of the posterior capsule. Because of remeval of HU from the culture medium on the Srd day the crystalline lens had become lucid on the 6th day, approximately the same as that of the controief the 6th day, In a histopathol-
منابع مشابه
An electron microscopic study of early reversible hydroxyurea cataracts in vitro.
The crystalline lenses of male white Wistar rats weighing 100 gr. were cultured in a culture fluid containing 5 X 10(-2) M hydroxyurea. The epithelial cells forming multiple layers in the equatorial region on the 4th day of incubation and swollen epithelial cells were studied by electron microscopy and the results are summarized as follows; The epithelial cells forming multiple layers retained ...
متن کاملComparison of optical coherence tomography imaging of cataracts with histopathology.
This paper presents a comparison of in vivo optical coherence tomography (OCT) captured cataract images to subsequent histopathological examination of the lenticular opacities. OCT imaging was performed on anesthetized Rhesus monkeys, known as the delayed effects colony (DEC), with documented cataracts. These monkeys were exposed to several types of radiation during the mid and late 1960s. The ...
متن کاملBifurcation of limit cycles from a quadratic reversible center with the unbounded elliptic separatrix
The paper is concerned with the bifurcation of limit cycles in general quadratic perturbations of a quadratic reversible and non-Hamiltonian system, whose period annulus is bounded by an elliptic separatrix related to a singularity at infinity in the poincar'{e} disk. Attention goes to the number of limit cycles produced by the period annulus under perturbations. By using the appropriate Picard...
متن کاملPrevalence of Age-related Cataracts in Population Older than 40 Years in Iranshahr
Purpose: To investigate the prevalence of age-related cataracts in people older than 40 years, urban and rural regions covered by Iranshahr University of Medical Sciences in 2016. Methods: This is a cross-sectional study (descriptive and analytic), in which all urban and rural population were screened by Iranshahr University of Medical Sciences. The primary screening examination in the health c...
متن کاملRole of XmnIgG Polymorphism in Hydroxyurea Treatment and Fetal Hemoglobin Level at Isfahanian Intermediate β-Thalassemia Patients
Background: &beta-thalassemia is the most common monogenic disorder in human. The (CT) polymorphism at -158 upstream region of the &gammaG-globin gene and pharmacological factors such as hydroxyurea have been reported to influence &gamma-globin gene expression and the severity of clinical symptoms of &beta-thalassemia. Methods: In the present study, 51 &beta-thalassemia intermediate patients w...
متن کامل